![]() ![]() The efficacy of cellulose is associated with the maintenance and release of growth factors at the site of injury, which promote the migration and proliferation of fibroblasts and inhibit bacterial growth in the wound. Cellulose resorption does not occur in the cells because animal cells do not produce cellulose enzymes. Good preliminary results were shown by studies with the inclusion of chitosan and cellulose in dressings. Recently, promising results have been demonstrated using multicomponent dressings based on biomaterials such as stem cells and polymers. It is obvious that the development of safe and effective new medicines for the treatment of wounds is urgent. The results of meta-analyses and systematic reviews of the effectiveness of different agents and methods used to treat wounds demonstrate the lack of a uniform and effective approach, as well as a limited choice of drugs for use in wound treatment. Despite the constantly increasing number of drugs and methods used to treat wounds, the problem of effective regeneration has not yet been resolved. Added to this is the trend of increased life expectancy, and hence comorbidity, which is accompanied by a growing prevalence of chronic trophic ulcers of various etiologies that are becoming an acute clinical problem. One compelling explanation is the increased number of surgical operations in the world, as well as the increased number of wounds caused by domestic disputes and military actions, which are responsible for a somatically healthy person receiving an acute wound. Questions concerning how a variety of wounds heal and effective medical support of the healing process remain open to debate and of immediate concern. The proven efficacy of developed polymeric compounds demonstrates the feasibility of further studies in clinical practice. DHCB did not affect the rate of healing for acute wounds without ischemia during the first week. ![]() Invasive drugs and DCh slowed the regeneration process. The treatments in the PCCD and MSC groups were more effective than in the DHCB and DCh groups. The most effective remedy was combination PCCD + MSC. After 14 days, we evaluated the state and size of the wounds, studied the level of microcirculation, performed a histological study, and identified and counted the different types of cells. Eight groups were studied: Control_0-intact wounds Control_ss-0.9% NaCl injections MSC injections Control_msc-intact wounds on the opposite side of the body from the MSC group external application of the PCCD external application of a combination of the drugs PCCD + MSC DCh –ointment Dioxomethyltetrahydropyrimidine + Chloramphenicol and DHCB-injections of a deproteinized hemoderivative of calf blood. Two wounds were made on the backs of each of 112 Wistar rats, removing the skin. We studied the efficacy of using mesenchymal stem cells (MSC) and a polymeric compound (based on chitosan and cellulose with integrated cerium dioxide nanoparticles (PCCD)) in wound healing, and to compare the effects with various invasive and external drugs used for the same purpose. ![]()
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